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ОЗОН Фармацевтика

Тамоксифен таблетки 20мг 30шт

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549 купили
Артикул Market
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Количество в упаковке
Рецептурный препарат
Тип препарата
Назначение
Инструкция
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Тамоксифен таб.
Тамоксифен таблетки 20мг 30шт
549 купили
Задать вопрос
Нет в продаже
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ЗдравСити - сервис заказа и выдачи лекарств
Магазин4.9 (133.1K оценок)
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Инструкция
Артикул Market
103544335800
Бренд
ОЗОН Фармацевтика
Количество в упаковке
30 штук
Тип препарата
лекарственный препарат
Рецептурный препарат
да
Органы и системы
молочные железы, половые железы
Назначение
рак молочной железы
Показания к применению
- Адъювантная терапия раннего рака молочной железы с эстроген-положительными рецепторами.
- Лечение местно распространенного или метастатического рака молочной железы с эстроген-положительными рецепторами.
- Рак грудной железы (в т.ч. у мужчин после кастрации).
Тамоксифен также можно применять при других солидных опухолях, резистентных к стандартным методам лечения, при наличии гиперэкспрессии рецепторов эстрогена.
Противопоказания
Повышенная чувствительность к тамоксифену и/или любому другому компоненту препарата; беременность и период лактации. Детский возраст (данные по эффективности и безопасности у детей отсутствуют).
Состав
1 таблетка 10 мг содержит:
Действующее вещество: тамоксифена цитрат - 15,2 мг, в пересчете на тамоксифен - 10,0 мг.
Вспомогательные вещества: лактозы моногидрат (сахар молочный) - 62,0 мг, целлюлоза микрокристаллическая (МКЦ-101) - 10,0 мг, крахмал кукурузный - 7,3 мг, повидон-К25 - 3,5 мг, карбоксиметилкрахмал натрия - 1,0 мг, магния стеарат - 1,0 мг.
1 таблетка 20 мг содержит:
Действующее вещество: тамоксифена цитрат - 30,4 мг, в пересчете на тамоксифен - 20,0 мг.
Вспомогательные вещества: лактозы моногидрат (сахар молочный) - 124,0 мг, целлюлоза микрокристаллическая (МКЦ-101) - 20,0 мг, крахмал кукурузный - 14,6 мг, повидон-К25 - 7,0 мг, карбоксиметилкрахмал натрия - 2,0 мг, магния стеарат - 2,0 мг.

Действующее вещество
Тамоксифен
Способ применения и дозы
Внутрь, не разжевывая, запивая небольшим количеством жидкости, в один прием утром, или, разделяя необходимую дозу на два приема (утром и вечером).
Режим дозирования обычно устанавливается индивидуально в зависимости от показаний. Суточная доза составляет 20-40 мг. В качестве стандартной дозы рекомендуется прием 20 мг тамоксифена внутрь ежедневно длительно. При появлении признаков прогрессирования заболевания прием препарата отменяют.
Побочные действия
При лечении тамоксифеном наиболее часто встречаются побочные реакции, связанные с его антиэстрогенным действием, проявляющиеся в виде приступообразных ощущений жара ("приливов"), влагалищных кровотечений или выделений, зуда в области гениталий, алопеции, болей в области очага поражения, оссалгии, увеличения массы тела.
Менее часто или редко наблюдались следующие побочные реакции: задержка жидкости, анорексия, тошнота, рвота, запор, повышенная утомляемость, депрессия, спутанность сознания, головная боль, головокружение, сонливость, повышение температуры тела, кожная сыпь (включая отдельные сообщения о мультиформной эритеме, синдроме Стивенса-Джонсона и буллезном пемфигоиде), нарушение зрения, включая изменения роговицы, катаракту и ретинопатию, ретробульбарный неврит. Очень редко наблюдался интерстициальный пневмонит.
В начале лечения возможно местное обострение болезни - увеличение размера мягкотканных образований, иногда сопровождающееся выраженной эритемой пораженных участков и прилегающих областей, которое обычно проходит в течение 2 недель.
Может возрасти вероятность возникновения тромбофлебитов и тромбоэмболий.
Часто отмечаются судороги ног.
Иногда могут наблюдаться транзиторная лейкопения и тромбоцитопения, а также увеличение активности “печеночных” ферментов, очень редко сопровождающееся более тяжелыми нарушениями функции печени, таких как жировая инфильтрация печени, холестаз и гепатит.
Редко наблюдалось повышение уровня сывороточных триглицеридов в некоторых случаях сочетавшегося с панкреатитом.
У некоторых пациентов с метастазами в кости в начале лечения наблюдалась гиперкальциемия.
Тамоксифен вызывает аменорею или нерегулярность наступления менструаций у пациенток в предклимактерическом периоде, а также обратимое возникновение кистозных опухолей яичников.
При длительном лечении тамоксифеном могут наблюдаться изменения эндометрия, включающих гиперплазию, полипы, развитие миомы матки и в единичных случаях - рак эндометрия, саркома матки.
Фармакологическое действие
Тамоксифен является нестероидным антиэстрогенным средством, обладающим также слабыми эстрогенными свойствами. Его действие основано на способности блокировать рецепторы эстрогенов. Тамоксифен, а также некоторые его метаболиты конкурируют с эстрадиолом за места связывания с цитоплазматическими рецепторами эстрогена в тканях молочной железы, матки, влагалища, передней доли гипофиза и опухолях с высоким содержанием рецепторов эстрогена. В противоположность рецепторному комплексу эстрогена рецепторный комплекс тамоксифена не стимулирует синтез ДНК в ядре, а угнетает деление клетки, что приводит к регрессии опухолевых клеток в результате их гибели.
Фармакологическая группа
антиэстрогенное средство
Форма выпуска
таблетки
Способ применения/введения
пероральный
Условия хранения
В сухом, защищенном от света месте при температуре не выше 25 °С. Хранить в недоступном для детей месте.
Передозировка
Острая передозировка тамоксифеном у человека не наблюдалась. При передозировке возможно развитие нейротоксичности (тремор, гиперрефлексия, шаткость походки, головокружение). Специфический антидот не известен. Лечение симптоматическое.
Применение при беременности и кормлении грудью
Противопоказано.
Влияние на способность управлять транспортом и механизмами
В период лечения необходимо соблюдать осторожность при вождении автотранспорта и занятии потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций.
Особые указания
С осторожностью:
заболевания глаз (в т.ч. катаракта), выраженный тромбофлебит, тромбоэмболическая болезнь (в т.ч. в анамнезе), гиперлипидемия, лейкопения, тромбоцитопения, гиперкальциемия; наследственная непереносимость лактозы, недостаточность лактазы или нарушение всасывания глюкозы и галактозы (препарат содержит лактозу).
Женщины, получающие тамоксифен, должны подвергаться регулярному гинекологическому обследованию. При появлении кровянистых выделений из влагалища или влагалищных кровотечениях прием препарата следует прекратить. Тамоксифен может вызывать овуляцию, что повышает риск беременности, в связи с чем, женщинам репродуктивного возраста необходимо использовать надежные методы контрацепции (негормональные) в период лечения и в течение 3 месяцев после окончания лечения.
У больных с метастазами в кости периодически во время начального периода лечения следует определять концентрацию кальция в сыворотке крови. В случае выраженных нарушений (гиперкальциемии) прием тамоксифена следует временно прекратить.
При появлении признаков тромбоза вен нижних конечностей (боль в ногах или их отечность), эмболии легочной артерии (одышка) прием препарата следует прекратить.
В период терапии необходимо периодически контролировать показатели свертывания крови, содержание кальция в крови, картину крови (лейкоциты, тромбоциты), показатели функции печени, артериальное давление, проводить осмотр у окулиста.
У больных с гиперлипидемией в процессе лечения необходимо контролировать концентрацию холестерина и триглицеридов (ТГ) в сыворотке крови.
Взаимодействие
При одновременном назначении тамоксифена и цитостатиков повышается риск тромбообразования.
Имеются сообщения о потенцировании тамоксифеном антикоагуляционного эффекта препаратов кумаринового ряда (например, варфарина).
Препараты, снижающие выведение кальция (например, диуретики тиазидового ряда), могут увеличивать риск развития гиперкальциемии.
Совместное применение тамоксифена и тегафура может способствовать развитию активного хронического гепатита и цирроза печени.
Одновременное применение тамоксифена с другими гормональными препаратами (особенно, эстрогенсодержащими контрацептивами) приводит к ослаблению специфического действия обоих препаратов.
При одновременном применение тамоксифена и бромокриптина наблюдается увеличение концентрации тамоксифена и N-десметил тамоксифена в плазме крови. Тамоксифен не должен применяться одновременно с ингибиторами ароматазы (аримидекс, летрозол).
Регистрационный номер
ЛСР-010503/09, ЛП-№(000730)-(РГ-RU)
Дата государственной регистрации
25.03.2019, 25.04.2022
Бренд
ОЗОН Фармацевтика
Изготовитель
ОЗОН
Фасовщик
ОЗОН
Страна бренда
Россия
Страна-производитель
Россия
Название препарата
Тамоксифен
Срок годности
35 мес.
- Адъювантная терапия раннего рака молочной железы с эстроген-положительными рецепторами.
- Лечение местно распространенного или метастатического рака молочной железы с эстроген-положительными рецепторами.
- Рак грудной железы (в т.ч. у мужчин после кастрации).
Тамоксифен также можно применять при других солидных опухолях, резистентных к стандартным методам лечения, при наличии гиперэкспрессии рецепторов эстрогена.
Повышенная чувствительность к тамоксифену и/или любому другому компоненту препарата; беременность и период лактации. Детский возраст (данные по эффективности и безопасности у детей отсутствуют).
Внутрь, не разжевывая, запивая небольшим количеством жидкости, в один прием утром, или, разделяя необходимую дозу на два приема (утром и вечером).
Режим дозирования обычно устанавливается индивидуально в зависимости от показаний. Суточная доза составляет 20-40 мг. В качестве стандартной дозы рекомендуется прием 20 мг тамоксифена внутрь ежедневно длительно. При появлении признаков прогрессирования заболевания прием препарата отменяют.

Отзывы

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50 оценок3 отзыва
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Достоинства:Работают
Недостатки:Побочки
Комментарий:А что делать?
Достоинства:таблетки от рака
Недостатки:пока их нету
Комментарий:Нет опыта в применении. Принимала Синфен, его нет в аптеках Воронежа, поэтому вынуждена принимать этот препарат, прерываться нельзя, назначено онкологом против рецидива рака молочной железы.
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